Cancer and Polymeric-Carriers

Nano-sized Polymeric Carriers for Cancer Diagnostics and Therapy

Drugs administered to treat cancers typically distribute randomly throughout the body, resulting in a lower concentration of the drug at the tumor and some severe side effects due to the lack of specificity of the anticancer agent. Targeted drug delivery systems have the potential to offer more effective treatment with significantly reduced adverse effects through specific interactions with the...

Polymeric Nanogels as Gene Carriers

Polymeric Microparticles as Alternative Carriers for Antidiabetic Glibenclamide Drug

Background: Glibenclamide is a lipophilic drug widely used in type 2 diabetes treatment. However, its low bioavailability limits its use. Thus, novel formulations should be applied to improve the drug’s bioavailability. Objectives: This study aimed to develop alternative carriers for oral delivery of glibenclamide. For this purpose, two biocompatible polymers, poly(e-caprolactone) and poly(but...

construction of polyurethane polymeric-based nano-carriers for curcumin in cancer therapy

objective: in order to improve the water solubility and bioavailability of curcumin in cancer therapy, we prepared and tested a novel waterborne cationic polyurethane (pu) as a nano-carrier for curcumin loading (cu-pu). we studied the effect of this prepared nano-drug on melanoma (f10b16) and fibroblasts cells (l929). methods: morphology, size and cell internalization ability of the prepared n...

Polymeric Nano-Micelles as Novel Cargo-Carriers for LY2157299 Liver Cancer Cells Delivery

LY2157299 (LY), which is very small molecule bringing high cancer diffusion, is a pathway antagonist against TGFβ. LY dosage can be diluted by blood plasma, can be captured by immune system or it might be dissolved during digestion in gastrointestinal tract. The aim of our study is to optimize a "nano-elastic" carrier to avoid acidic pH of gastrointestinal tract, colon alkaline pH, and anti-imm...